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Classification of Atypical Melanocytic Nevi Clinical Classification The clinical diagnosis of atypical melanocytic nevi is established when at least three of the following characteristics are present: Diameter greater than 5 mm Ill-defined borders Irregular margin Varying shades in the lesion Presence of papular and macular components

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23,36 However, even this risk remains low, with the highest reported incidence of insulin autoimmune syndrome at 0.017 per 100 000 in Japan

2,10,22,23 This discrepancy may be explained by a selection bias inherent to the nature of our institution, which represents a major national and international referral center, attracting complex and advanced cases