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AMP-activated protein kinase (AMPK), a sensor for AMP and ADP, inhibits mechanistic target of rapamycin (mTOR) phosphorylation, thereby suppressing the expression of hypoxia-inducible factor 1-alpha (HIF-1), the master transcriptional regulator of glycolysis (Peek et al., 2017)

pylori group compared with RPL15 knockdown groups and the negative control group (Additional file 1: Figure S2A)

[DOI] [PubMed] [Google Scholar] Botter SM, Zar M, van Osch GJ, van Steeg H, Dolle ME, Hoeijmakers JH, Weinans H, van Leeuwen JP

Oral administration of withaferin A inhibits carcinogenesis of prostate in TRAMP model

A reduction in peripheral neuropathy in the GSH-implementation arms was demonstrated in different neoplasms (head and neck cancer, non-small cell lung cancer, ovarian cancer, gastric cancer, colorectal cancer), suggesting a possible neuroprotective effect of this substance