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Moreover, persistent hyperglycaemia triggers activation of the (NF-B) pathway and release of pro-inflammatory factors, leading to an imbalance between the pro- and anti-inflammatory networks, resulting in an increase in reactive oxygen species and the production of a large number of inflammatory mediators, which affects the functioning of the mitochondria and leads to neuronal damage and degeneration (29)

2009;4(4):e5186

doi: 10.4172/2329-8901.1000134 228 SinghalAKumarS

doi: 10.1210/jcem-63-6-1313

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Further work will be needed to determine the lifespan benefit attributable to augmentation of peroxisomal acl-7 or ads-1 activity, and whether any benefit is mechanistically similar to fard-1 overexpression