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Tissue-bound peptide activity persists significantly longer
10.1152/physiolgenomics.00026.2019 Physiol

But even then, maintenance is key
So what do we know from the anecdata
In addition to controlling the production of nerve and blood cells, B12 plays a key role in the building process in your DNA
Most people are going to get that peak benefit around that timeframe, but there's a percentage of the population that are delayed responders that have maximum benefit four to six hours after they take a dose
