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Wen W, Zhu F, Zhang J, Keum YS, Zykova T, Yao K, et al

A breakdown in the intestinal barrier functions, therefore, increases the susceptibility of the HIV patients to severe bacterial infections [67] and predispose the patients to the complications due to chronic inflammation and dysregulated immune responses

However, systemic administration of naked adenoviruses may induce severe hepatotoxicity and trigger rapid immune responses in the host due to their highly immunogenic viral capsids, leading to severe inflammatory reactions [32, 40]

Dis Models Mech

Cholesterol can not only induce ectopic fatty acids accumulation, reshape an immunosuppressive microenvironment, activate hepatic stellate cells, and influence membrane fluidity or protein function, to further promote tumorigenesis in HCC but also activate NK cell proliferation or recruitment, and promote CD44 translocation into lipid rafts, so that prohibit HCC (Zhou and Sun, 2021)

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