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Mechanistic studies reveal that acetyl-L-carnitine enhances cholinergic neurotransmission by increasing acetylcholine synthesis and release, upregulates nerve growth factor (NGF) expression, improves mitochondrial membrane potential and respiratory function in neurons, reduces oxidative damage to neural lipids and proteins, and modulates synaptic plasticity and neurotransmitter receptor function

Due to insufficient blood supply, rapidly growing tumors in vivo are often hypoxic, and it is conceivable that this could enhance the therapeutic efficacy of APR-246, both in wild type and mutant TP53-carrying tumors

Investigation of the presence of ghrelin in the central nervous system of the rat and mouse

[PubMed: 10946219] 314

In laboratory and educational research, peptide blends are often used to explore complex biological responses that involve more than one pathway

Ethics declarations Competing interests M.D.P