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In participants with moderate-to-severe cognitive impairment (defined by MMSE), a larger improvement in cognitive performance was observed for donepezil and memantine, and their combination (donepezil +memantine), and these efficacy-related results are expected to also be reflected when a future study becomes available
Cappel, D., Jerome, S., Hessler, G

J Affect Disord 136:933939 Mahmoudi M, Bayat AH, Boroujeni ME et al (2019) Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP
These results suggest that PARG inhibition is effective for not only degrading BRD family proteins but also degrading another chromatin regulator, CDK9
PMC 283344
