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Epigenetic and disease prevention: effects of phytochemicals

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Andrologia 49(10):e12762 Aitken R, Smith T, Lord T, Kuczera L, Koppers A, Naumovski N, Connaughton H, Baker M, De Iuliis G (2013) On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid

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J Histotechnol

These findings collectively demonstrate that EC metabolism involves a coordinated sequence of intestinal absorption, hepatic and colonic biotransformation, and renal elimination, with distinct phase II conjugates acting as clearance intermediates and serving as characteristic metabolic signatures of EC exposure (Figure 3)