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In monocytes and macrophages, caspase-1 activates caspases-3/7 and induces apoptosis in the absence of GSDMD while caspases-3/7 specifically block pyroptosis by cleaving GSDMD during apoptosis, which is called bidirectional crosstalk [169]
Detoxification cleanses the liver and removes toxins

Focal ischemic stroke leads to lung injury and reduces alveolar macrophage phagocytic capability in rats

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Nat Med 22(8):879888

Anticancer activity Effects on carcinogen metabolism Inhibition of metabolic activation of carcinogens Some chemical carcinogens do not become active carcinogens until they have been metabolized by Phase I biotransformation enzymes, such as those belonging to the cytochrome P450 (CYP) family
