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Additional information Peer review information Nature Communications thanks Keith Blackwell and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Transporter dysfunction within the endolysosomal system leads to diverse systemic phenotypes

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The urate and xanthine concentrations in the cerebrospinal fluid in patients with vascular dementia of the Binswanger type, Alzheimer type dementia, and Parkinsons disease

Other biosynthesis As described earlier, glutamine is required for two steps in purine biosynthesis, whereas aspartate, which acquires its nitrogen from glutamate, is required for a step in purine biosynthesis and a step in pyrimidine biosynthesis