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Pourreza, Y
5, 29672969.10.1111/j.1743-6109.2008.00918.x 87 RussellS.SteersW.McVaryK

Programmed cell death pathways that involve autophagy, apoptosis, ferroptosis, and pyroptosis can play a critical role in metabolic and neurodegenerative disorders and oversee processes that include insulin resistance, -cell function, mitochondrial integrity, reactive oxygen species release, and inflammatory cell activation

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Several pathophysiologic mechanisms have been postulated, such as autonomic abnormalities, hypothalamic-pituitary-adrenal (HPA) activation, genetic abnormalities, neuronal hyperexcitability, and gastric dysmotility