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Despite its significant potential, GO faces significant challenges, including scalability limitations, long-term stability concerns, and reproducibility/regeneration issues, which have been addressed with possible solutions, including health concerns for its sustainable futuristic applications.

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In support of its pro-longevity profile, researchers have noted that higher MOTS-c levels correlate with healthier aging markers in both animals and humans, implying that maintaining MOTS-c might benefit aging tissues

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