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A 12-week facial study on 67 women indicated that GHK-Cu cream applied twice daily improved aged skin appearance, increased thickness, reduced wrinkles and strongly stimulated dermal keratinocyte proliferation as determined by histological analysis of biopsies

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Nuclear exclusion of p53 reportedly leads to translocation of p53 to mitochondria and transcription-independent induction of apoptosis [28], which may explain the therapeutic effect of FOXO4-DRI

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