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It is important to note that mitochondria are indispensable in all types of cell death, and consequently, in ASD pathogenesis

For instance, elevated CXCL10 in vitiligo lesions not only attracts CD8 + T cells but also stimulates these cells to secrete additional IFN-, which further enhances CXCL10 expression, forming a self-amplifying inflammatory cycle

also demonstrated that Asn levels are increased in activated CD8 + T cells and bind to the SRC family tyrosine kinase LCK, assisting in the phosphorylation of LCK at Tyr394 and 505, enhancing LCK activity and T-cell receptor signaling

It is from this role in cation transport regulation that the ChaC-like enzyme family derives its alternative name: cation transport regulator-like proteins (Radchenko et al., 2006)