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10.1016/j.heliyon.2020.e04716 45 OuZ.PanJ.TangS.DuanD.YuD.NongH.et al (2021)

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Wild type SOD1 can be misfolded by the aberrant translation, post-translational modification or oxidative modifications, due to the pathological conditions of the CNS environment, and produce toxic insoluble aggregates, as mutated SOD1 (Bosco et al., 2010