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Kaiser et al., 2011

Enzyme kinetics of cytochrome P450-mediated reactions

The prolongation of apparent half-life with multiple dosing is characteristic of drugs that undergo distribution into deep tissue compartments from which elimination is slow, creating a multi-exponential elimination profile

A few years later, a randomized controlled trial in 18 subjects with treatment-resistant depression showed a similar rapid, robust response after a single dose that waned over the course of 1 week (Zarate et al., 2006), she said

Cardiac aging in mice is characterized by a decline in diastolic function 29 , which we confirmed by a reduction in the E/A ratio with age in both sexes (Fig

Neurotrophin-directed differentiation of human adult marrow stromal cells to dopaminergic-like neurons