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The transport mechanism of CLCs has been well established by structural studies which revealed a homodimeric architecture with each protomer bearing a separate ion transport pathway and three consecutive substrate-binding sites referred to as the external site (S ext ), central site (S cen ) and internal site (S int ) 15,16,17,18,19,20,21,22,23,24,25

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AA donates its electrons to scavenge for and neutralize reactive oxygen species (ROS) like superoxide

2016 Aug 1;176(8):1134-45