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After evaluating the best candidate, we then showed that ES2 colocalized to FOXO4 foci and preferentially bound FOXO4 over TP53

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doi: 10.1007/s12223-019-00706-2 40 SekirovIRussellSLCaetano M AntunesLFinlayBB

Without adequate closing pressure from the lower esophageal sphincter, stomach acid inevitably escapes into the esophagus regardless of how effectively medications reduce overall acid production

Gastrointestinal symptoms are very common, with nausea affecting approximately 1 in 3 patients in clinical trials