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10.4077/cjp.2009.amh036 12 ChenM.JiangL.LiY.BaiG.ZhaoJ.ZhangM.et al (2017)

These procedures all cleave peptide chains at designated locations, and at the carboxyl side of the targeted amino acid

It works by suppressing the tyrosinase enzyme and shifting melanin synthesis from darker eumelanin to lighter pheomelanin

Rapid plasma degradation and limited, variable BBB transport make systemic peripheral dosing of the parent peptide an inefficient route of exposure for any putative central target

(10%), the bulk of the requirement (90%) is met via the conversion above pathway

10.1038/311029a0 Nature 16 CrepaldiT.PratM.GiordanoS.MedicoE.ComoglioP
