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However, translating this substantial preclinical rationale into clinical practice necessitates rigorous, large-scale randomized controlled trials to substantiate their efficacy and safety in human populations
Upon binding to AREs in the nucleus, NRF2 interacts with other co-activators, such as the CBP/p300 protein, forming a complex that further activates the transcription of antioxidant and detoxification genes [30]
Di Pasqua, L
10.1042/bj1640185 22
La combinacin con una psicoterapia especfica para el TOC, especialmente la terapia cognitivo-conductual con exposicin y prevencin de respuesta, logra los mejores resultados gracias al efecto sinrgico
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