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"Alcohol dehydrogenase from Lactobacillus brevis : A versatile catalyst for enenatioselective reduction" (PDF)

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Example of toxic acetylated metabolite Liver damage Highly reactive specie Mechanism of acetylation Acetyl CoA is the activated carrier for acetyl group The reaction catalyzed by the soluble acetyltransferase enzyme: Mainly found in liver Might found in lung, spleen, GIT and red blood cells Acetylation The rate of acetylation is mainly affected by the existence of genetic polymorphism