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Both O and N -glucuronides can be cleaved back to the active parent compound in the intestines through the action of -glucuronidases produced by gut bacteria

This followed the guidelines set out by the consensus statement from PRISMA group ( We identified seven additional eligible datasets, along with the 13 located in 2018 (details below)

PMID: 23356518

PLoS One 12:e0169526

Subsequently, the N -Boc- p -benzoquinone imine was allowed to react with L-cysteine in 100 mM phosphate buffer at physiological pH to afford the protected S -(5-(( tert -butoxycarbonyl)amino)-2-hydroxyphenyl)-L-cysteine ( N -Boc-PAP-CYS

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