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It is important to note that mitochondria are indispensable in all types of cell death, and consequently, in ASD pathogenesis

doi: 10.1016/j.dnarep.2008.03.012

1.4.3 Limitations of benign and VUS classifications Ultimately, WES is not a genetic oracle, and in contrast to Mendelian diseases which often result from single-gene coding variants (Botstein and Risch, 2003), several complex traits could be driven by noncoding variants that presumably affect gene regulation

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Furthermore, these advantages contribute to a broader and more versatile therapeutic scope, which significantly drives research into the development of targeted delivery systems [85]