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doi: 10.1523/JNEUROSCI.3955-14.2015

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Potential ROS sources and the role of oxidative stress in keratoconus are shown in Fig

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Additionally, estrogen-stimulated cyclooxygenase-2 (COX-2) activity drives prostaglandin E2 (PGE2) synthesis, creating a positive feedback loop that enhances local estrogen production and inflammation, further facilitating ectopic implantation (19)

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