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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

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Different mixing ratios and pharmacy concentrations result in different measurements, even for the same dose

In the tirzepatide trials, nearly 9 out of 10 participants on the higher doses achieved clinically meaningful weight loss