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Description
Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) is one of the most widely used immune checkpoint inhibitors in clinical applications (Ribas and Wolchok, 2018)

Signal integration is accomplished by the assembly of cytosolic pattern recognition receptors (PRRs), including nucleotide oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 1 (NLRP1), NLRP3, NLRC4, absent in melanoma 2 (AIM2), and pyrin, and activation of caspase-1

L.KimK.-W.et al (2020)

According to the authors, LRIF1 mutations are a rare reason for FSHD and should thus only be considered in FSHD2 when tested negative for SMCHD1 mutations [47]
It is found in virtually every cell in the human body
A value of 100% for the predefined critical effect sizes represents a two-fold change, which was also used in the present study to define a biologically relevant effect in the in vitro comet assay thus compensating for data variability and avoiding potentially false-positive results
