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Nat Rev Dis Primers 2018;4:16

A prognostic model was built with Cox and Least Absolute Shrinkage and Selection Operator (LASSO) methods and validated by Kaplan-Meier analysis, Receiver Operating Characteristic (ROC) curves, and Principal Component Analysis (PCA)
It is important that there is clear guidance in the study design on what to do when adverse effects occur after sentinel dosing

Diamantopoulou et al

Its activity is centered on modifying cell fate decisions within damaged cellular populations

Its also known to cause other unpleasant side effects, from body odor to diarrhea