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Specific Evidence for No IGF-1 Effects: Blood samples collected at baseline and throughout the treatment period measured serum IGF-1 concentrations using validated immunoassays

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Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation