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Although we are unable to directly assess site-specific LepR ICD phosphorylation with available reagents, these results indicate that phosphorylation of Tyr1141 may occur more efficiently than phosphorylation of Tyr986, such that reducing stability of the 2:2 complex more substantially impacts phosphorylation at Tyr986

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Child Mind Institute

Together, these pathways are often examined in relation to energy balance , glucose-dependent signaling behavior, nutrient-response timing, and coordinated metabolic regulation across interconnected endocrine and gastrointestinal environments

CMLS 75 (17), 31433157

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