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Further analysis of the transcriptome and metabolome data of the ripe fruits of the mutant and the wild-type showed that TF EIL2 is involved in the accumulation of -carotene through direct regulation of the expression of the SlERF.H30 and SlERF.G6 genes, which, in turn, are involved in the regulation of the LCY gene in tomatoes (SlLCYB2) [67]

For instance, HK2, the first rate-limiting enzyme in glycolysis, localizes to the nucleus, where it interacts with chromatin-associated factors such as 53BP1 and RAD51, potentially influencing the DDR [145]

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Therefore, future investigations into oxidative stress markers as potential early diagnosis and therapeutic target of ASD are necessary

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To assess Gpx4 level quantitatively, protein extracts of lumbar spinal cord tissues were obtained and then probed with an anti-Gpx4 antibody