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The body essentially adapts to the presence of the signaling molecule and requires increasingly higher doses to achieve the same effect

9,19 There are no prospective randomized studies on the safety of cimetidine and other H 2 RAs during pregnancy, but the general consensus is that cimetidine and possibly famotidine are safe

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People allergic to cobalt or cobalamin, those with Lebers hereditary optic neuropathy , and those with severe hypersensitivity should be careful with B12 supplements

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