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Moreover, the acidic assay conditions (pH 3.6) can precipitate proteins (e.g., milk casein) and generate pro-oxidant Fe 2+ ions, which may propagate radical chain reactions (Pulido et al., 2000

Helfinger V, Palfi K, Weigert A, Schrder K

Thus, GPX1 overexpressing -cells produce more insulin, whereas -cell mass is reduced in GPx1 deficient mice, leading to hypoinsulinemia and decreased glucose-stimulated insulin secretion [96]

Jpn Pharmacol Ther 48:685697 Yang NC, Lin HC, Wu JH, Ou HC, Chai YC, Tseng CY, Liao JW, Song TY (2012) Ergothioneine protects against neuronal injury induced by -amyloid in mice

Doxorubicin, on the other hand, generates free radicals, causing intracellular oxidative damage and further activating apoptotic signaling pathways [470, 471]

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