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Figure 5 8.1 Estrogen and age-related inflammaging The pathogenesis of PMO is deeply intertwined with both age-related senescence and acute estrogen deprivation

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As we age or encounter stressors such as poor diet, environmental toxins, or chronic illness, our body's levels of glutathione can decline

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The 4-hydroxyestrone pathway is additionally influenced by environmental toxins, so patients who have CYP1B1 SNPs are especially susceptible to estrogen-sensitive cancers

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