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Two different selenium-dependent iodothyronine deiodinases (DIOs type 1 and 2) can deiodinate T 4 , thus increasing circulating T 3 , while a third iodothyronine deiodinase (DIO type 3) can convert both T 3 and T 4 to inactive metabolites ( Figure 3 ) (10, 11)

However, in the context of metabolic dysfunction, including conditions such as obesity and MASLD, leptins role becomes more complex [211]

Increased GAD expression in the striatum after transient cerebral ischemia

Type I CSs are found in eukaryotes, archaea, and most gram-positive bacteria, whereas type II CSs are found in most gram-negative bacteria, including K