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Although small-molecule ferroptosis inhibitors, such as liproxstatin-1 and ferrostatin-1 (Fer-1), have been shown to protect against AKI (14, 15), the detailed pathogenic mechanisms of ferroptosis in the transition of AKI to CKD remain elusive

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SH2B1-IRS interactions also inhibit tyrosine dephosphorylation of IRS proteins, thus prolonging the activation of the IRS-PI3K pathway [156]

Of those, 13 agreed to take part in the randomized study

Blood 79 , 23402348 (1992)

Optimization study towards more potent thiazolidine-2,4-dione IKK-beta modulator: Synthesis, biological evaluation and in silico docking simulation