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21 Heriditary cystatin C amyloid angiopathy (HCCAA): Hereditary cystatin C amyloid angiopathy (HCCAA) is a rare dominantly inherited disease caused by a leucine to glutamine variant of human cystatin C (hCC)

Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, Tsouh Fokou PV, Azzini E, Peluso I, Prakash Mishra A, Nigam M, El Rayess Y, Beyrouthy ME, Polito L, Iriti M, Martins N, Martorell M, Docea AO, Setzer WN, Calina D, Cho WC, Sharifi-Rad J

Results in 24 months

Physiological Reviews, 84, 11551228

Reports of temporary tiredness or mild headaches when first starting have been reported

However, broader guidance from NICE, the NHS, and the MHRA provides a clear framework for understanding how unapproved substances should be approached