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In non-human primates, the highest GLP-1 immunoreactivity has been demonstrated in various nuclei of the hypothalamus, the area postrema, the NTS, and the dorsal motor nucleus of the vagus [389]

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As in the previous recommendations by the ADA and EASD (73, 74), life-style intervention (with patient education and motivation, increase of physical activity, and healthy eating) is still in the beginning and center of therapy, followed by pharmacological therapy with metformin (7074)

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Week 1-2 (initiation at 2.5 mg): Sleep changes are minimal for most users at the starting dose