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However, clinical translation is hindered by low oral bioavailability, limited BBB permeability, and inconsistent pharmacokinetics

456,457,458 The primary advantage of covalent conjugation is that the resulting product is a single compound with defined structural and stoichiometric characteristics, aligning with the ideal properties for drug design and in vivo application

Kamoun EA, Kenawy ES, Chen X (2017) A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

This reflex can be increased or decreased, or both, in spastic patients