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These results are consistent with the previous in vivo experiments using dextran with different molecular weights (3 to 2000 kDa), in which the opened BBB gaps ranged from 2.3 to 54.4 nm depending on the acoustic pressure 42,43

Hooda, Z, Duan, Z, Ries, S, Antonoff, MB, Hofstetter, WL, Mehran, RJ, Mitchel, KG, Rice, DC, Swisher, SG , Vaporciyan, AA, Walsh, GL, Rajaram, R

Savarino G, Corsello A, Corsello G

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Oxylipins were quantified using UHPLCMRMMS/MS on an EXIONLC System (SCIEX) coupled to a SCIEX 6500 QTRAP+ mass spectrometer equipped with an IonDrive Turbo V electrospray ionization (ESI) source

AOD-9604 sidesteps the insulin question entirely by not affecting glucose metabolism