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Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome

Upon MOMP, cytochrome c binds to apoptotic protease activating factor-1 (Apaf-1) in the cytoplasm, forming the apoptosome, which activates caspase-9
L.TigchelaarW.et al

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An increase in the NAD+:NADH ratio allows Treg cells to use lactate as a substrate to generate pyruvate for subsequent mitochondrial bioenergetics in a high-lactate and low-glucose microenvironment, such as the tumor microenvironment (TME) [163]
