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As a result, the binding affinity between PDIA6 and Ca 2+ weakened, with an increase in the dissociation constant ( K d ) from 271.0 33.3 to 857.0 153.0 M and a decrease in the change in free energy ( G ) from 4.86 0.07 to 4.18 0.11 kcal mol 1
These results show that pegvisomant impairs GH signaling

Therefore, treatment usually depends on the severity of the condition but it is advised to consult a healthcare provider before starting the supplement
Goldstein et al., 2012)

[DOI] [PubMed] [Google Scholar] 54.Guler HP, Zapf J, Froesch ER

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