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101 In rats with tail or foot amputation, and heparin, warfarin and aspirin application, without 62 or with nitric oxide (NO)-agents, NO synthase (NOS)-blocker N-nitro-L-arginine methyl ester (L-NAME) or NOS-substrate L-arginine, 63 prolonged bleeding and thrombocytopenia were counteracted

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260 This shows that Trx inhibits local Th2 cells to push the balance towards Th1 and suppress local inflammation while having no effect on the Th1/Th2 balance of the systemic immune system