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Description
Exposure to environmental toxins or heavy metals

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LGH00168, a novel CHOP activator, induces RIP1-dependent necroptosis via ROS-mediated NF-B inhibition and ER stress, significantly reducing tumor growth in vivo (Ma et al

On the other hand, depletion of GSH increases the toxicity of alkylating agents both in vivo and in vitro 43

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