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The endocannabinoid system is composed of the natural cannabinoids, anandamide and 2-arachidonoyl glycerol (2-AG), enzymes regulating their synthesis/catabolism, and the cannabinoid CB 1 and CB 2 receptors
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However, years before, Aguila [83] argued that the hypothalamic increase in NO induced by GHRH would act on SS neurons increasing both the synthesis and release of SS

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