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( E ) Volcano plot showing metabolite alterations in mouse livers following GSH depletion

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Phosphorylation of IRS-1 by p70S6K results in reduced insulin-mediated signaling via the insulin receptor, thereby, increasing the metabolic burden on pancreatic -cells

It is therefore important to conduct experiments for the development of in vivo diagnostics under relevant nutrient conditions, such as using synovial fluid for a more accurate representation of the PJI environment

From a breeding perspective, combining the Shirayama allele at qAAD11_1 ( TOF11 ) with the Enrei allele at qAAD11_2 is essential for high FAA accumulation, highlighting the importance of marker-assisted selection for these QTLs