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In bacteria, NAC acts as a cysteine donor for GSH biosynthesis, indirectly influencing the roles of GSH in GSH-producing bacteria

Effects: Same as sarin Routes of exposure: Same as sarin Treatment after exposure: Same as sarin except pralidoxime may be ineffective due to rapid aging caused by soman

Both OA-causing factors have been found to cause oxidative stress in chondrocytes

introduced Zr into a manganese porphyrin-based MOF (Mn-MOF) to construct a biocompatible nanosensitizer along with the capacity of GSH exhaustion-enhanced ferroptosis (Figure 5F) (Figure 5G), thus elevating Mn-MOF-induced ROS concentration, leading to the deactivation of GPX4 and ROS-enhanced ferroptosis

Since GSH is the final product of the homocysteine metabolism in the transsulfuration pathway by transferring sulfur from homocysteine to cysteine, a deficiency in transsulfuration pathway leads to excessive homocysteine production (hyperhomocysteinemia) and reduced GSH synthesis (159, 160)

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