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doi:10.1016/j.bmcl.2018.07.009

NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

Methylation and methyl donor status NNMT consumes methyl donors as part of its enzymatic function

Benefits of 5-Amino-1MQ While there are encouraging test tube and animal studies into the effects of 5-amino-1MQ, it is important to note that we still lack quality data in humans

However, when the assay was repeated with 5-amino-6-fluoro-1MQ, an analogue of 5-amino-1MQ that did not interfere with the NAMPT assay, no inhibition of NAMPT was observed with analogue concentrations between 30 and 600 M (data not shown)

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