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Finally, a cell cycle-dependent variation of the amount of GSTP1-1-TRAF2 complex existing in cells was detected, with a maximum in G 0 /G 1 and a strong decrease in S, G 2 , and M phases

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With increased inflammation and neutrophil recruitment, aggregation of NETs occurs causing the formation of aggNETs that contributes to the anti-inflammatory effect by engulfing and degrading MSU crystals together with the components such as NSPs