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As well as activating SIRT1, BBR is also able to decrease FOXO1 acetylation, triggering anti-apoptotic signaling pathways via Bcl-2 expression, and Bax and caspase-3 downregulation (Yu et al., 2016)
10.3390/genes13040654 75 FatimaS.SongY.ZhangZ.FuY.ZhaoR.MalikK.et al (2024)
This systematic review and meta-analysis did not include a very recent RCT in Denmark that also found a decrease in TPOAb titer following selenium supplementation but no difference in HRQoL between the placebo- and selenium-treated groups [59]
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