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Abstract Stroke stands as a predominant cause of mortality and morbidity worldwide, and there is a pressing need for effective therapies to improve outcomes and enhance the quality of life for stroke survivors

The gene family associated with tissue- nonspecific alkaline phosphatase (TNSALP) and several members of small integrin binding ligand N-linked glycoprotein (SIBLING) have been identified as androgen target genes required for androgen receptor (AR)-mediated bone formation 40

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A subsequent consensus review systematically organized and precisely defined the hallmarks of T-cell exhaustion [215]

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